4 S U P P L E M E N T T O O U T P A T I E N T S U R G E R Y M A G A Z I N E J U LY 2 0 1 5
Keep cool in the crisis with administration in
When MH strikes,
LESS THAN
1 MINUTE
Please see Brief Summary of full Prescribing Information on the following page.
References: 1. Data on le. Eagle Pharmaceuticals, Inc. 2. Managing an MH crisis. Malignant Hyperthermia
Association of the United States website. http://www.mhaus.org/healthcareprofessionals/managing-a-crisis.
Accessed June 18, 2014. 3. RYANODEX [package insert]. Woodcliff Lake, NJ: Eagle Pharmaceuticals, Inc.;
2014. 4. Dantrium Intravenous [package insert]. Rochester, MI: JHP Pharmaceuticals, LLC; 2008. 5. Revonto
[package insert]. Louisville, KY: US WorldMeds, LLC; 2011.
INDICATION
RYANODEX
®
(dantrolene sodium) for injectable
suspension is indicated for the treatment of malignant
hyperthermia in conjunction with appropriate supportive
measures, and for the prevention of malignant
hyperthermia in patients at high risk.
IMPORTANT SAFETY INFORMATION
RYANODEX
®
is not a substitute for appropriate supportive
measures in the treatment of malignant hyperthermia
(MH), including:
• Discontinuing triggering
anesthetic agents
• Increasing oxygen
• Managing the
metabolic acidosis
• Instituting cooling when necessary
• Administering diuretics to prevent
late kidney injury due to
myoglobinuria (the amount
of mannitol in RYANODEX
®
is
insuf cient to maintain diuresis)
© 2014 Eagle Pharmaceuticals, Inc. All rights reserved.
50 Tice Blvd, Suite 315 Woodcliff Lake, NJ 07677 (201) 326-5300 RYN14-0027-01 8/2014
ADVANCING THE STANDARD IN
MALIGNANT HYPERTHERMIA (MH) TREATMENT.
RYANODEX
®
(dantrolene sodium) for injectable suspension
is changing how MH is treated.
• Less time for reconstitution and administration
– Less than 1 minute for a loading dose (2.5 mg/kg) of dantrolene
sodium in an MH crisis
1,2
• Less risk of complications with less uid
– Over 99% less sterile water for injection than other dantrolene
sodium IV treatments
3-5
• Less effort to stay cool in an MH crisis
– 1 vial provides a loading dose for patients up to 100 kg and can be
administered by 1 healthcare professional (eg, an anesthesia provider)
1,3
To request that RYANODEX
®
be stocked in your institution or obtain
ordering information, visit RYANODEX.com/ops or call 855.318.2170.