no such thing as a perfect surgi-
cal mesh," Dr. Badylak thinks he's
developed a better mesh material,
a composite material that retains
the desirable mechanical proper-
ties of polypropylene without the
degree of scarring that occurs —
a mesh that allows for the repair
strength of a synthetic mesh
along with the remodeling char-
acteristics of a biologic graft and,
he says, "induces the body to
basically reform the absolute nor-
mal body wall that you were born
with."
This has been the focus of Dr.
Badylak's in-lab mesh develop-
ment: creating a new mesh mate-
rial that elicits a favorable
immune response, one that pro-
vides strength for years while the
body remodels in a friendly way
rather than forming scar tissue.
The new material looks and feels
like a synthetic mesh, he says,
but it's made (by synthetic
processes) of a naturally occur-
ring molecule in the body.
"Wound healing really is an
immune response," he says.
"Cells, instead of being pro-
inflammatory, they can actually
induce the formation of new
blood vessels and new muscle
tissue, and shut down the inflam-
matory response. That's a con-
cept that is totally foreign to
most surgeons.
"The hernia recurrence rate has
been 10 to 20% for so long that
people think that's acceptable. It's
become okay because they don't
understand or believe that it's pos-
sible to get lower recurrence
rates, better soft tissue outcomes
and fewer complications."
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