Inveltys is also the first product to employ the company's mucus-
penetrating particle (MPP) technology, which uses selectively sized
nanoparticles to more efficiently deliver the drug to target tissues,
says the company.
MKO Melt
The MKO Melt (mida-
zolam/ketamine/
ondansetron) has ush-
ered in "IV-free anes-
thesia." You give
patients 1 to 3 of the
non-opioid tablets,
which dissolve under
the tongue. You can give them in divided doses, first one and then
another if the patient's not sedated enough. Each sublingual troche is
$13, says Imprimis Pharmaceuticals.
How well does MKO Melt work? Anesthesiologist Maggie Jeffries,
MD, presented a poster at last month's American Academy of
Ophthalmology that summarized the results of her 600-plus-patient
study to compare the conscious sedation efficacy of MKO Melt to
diazepam (Valium) and a diazepam/tramadol/ondansetron combina-
tion during cataract surgery. The study — titled "Conscious sedation
efficacy of the novel medication, MKO Melt, during cataract surgery"
— measured how many patients anesthesiologists had to convert to
IV in the operating room due to anxiety or pain. The results: 26% of
the MKO patients required IV medication and 38% of the valium group
needed IV medication.
"IVs are one of the main discomforts of cataract surgery." says T.
Hunter Newsom, MD, founder of Newsom Eye & Laser Center in
7 6 • O U T PA T I E N T S U R G E R Y M A G A Z I N E • N O V E M B E R 2 0 1 8
• IV FREE MKO Melt is a non-opioid, non-invasive sublingual troche that lets patients
experience IV-free anesthesia.
Imprimis
Pharmaceuticals
