need to be frozen. As always, it's important to choose a reputable,
preferably 503B-designated, compounding pharmacy
(osmag.net/EN2rBp).
You can also purchase cefuroxime powder, and then reconstitute
and dilute it for intracameral injection. That is the preferred approach
of Val Zudans, MD, the CEO of Florida Eye Institute and Florida Eye
Institute Surgicenter in Vero Beach, Fla. His process, per the manufac-
turer's instructions: Add 7.5mL of preservative-free 0.9% saline (nor-
mal saline) to a 750mg vial of powder. Shake lightly and let sit for at
least 1 minute. Draw 1mL of the reconstituted cefuroxime and trans-
fer into a sterile empty vial. Add 9mL of preservative-free normal
saline, which yields the proper concentration of 10mg/mL.
"You can transfer this, 1mL at a time, into single-dose vials, or you
can draw up 1mL for a patient and discard the rest," says Dr. Zudans.
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1
1
Mixing, Diluting, or Repackaging Biological Products Outside the Scope of an Approved Biologics License Application Guidance for Industry
https://www.fda.gov/downloads/drugs/guidances/ucm434176.pdf
AvastinĀ® is a registered trademark of Genentech, Inc.
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